Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile
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چکیده
منابع مشابه
SYNTHESIS OF 8-HYDROXY-6-METHOXY- 3-UNDECYLISOCOUMARIN AND 2-HY DROXY - 4-METHOXY-6-(2-OXOTRIDECYL) BENZOIC ACID
Straightforward conversion of (+)-6,8-dimethoxy-3,4-dihydro-3- undecylisocoumarin (3) to the title isocoumarin was carried out. Hydrolytic ring opening of (3) afforded the hydroxy acid (4) which was immediately oxidized to keto acid (5) using chromic acid, Cyclodehydration of (5) afforded the 6,8- dimethoxy-3-undecylisocoumarin (6) which on selective demethylation of 8- methoxy group furni...
متن کاملsynthesis of 8-hydroxy-6-methoxy- 3-undecylisocoumarin and 2-hy droxy - 4-methoxy-6-(2-oxotridecyl) benzoic acid
straightforward conversion of (+)-6,8-dimethoxy-3,4-dihydro-3- undecylisocoumarin (3) to the title isocoumarin was carried out. hydrolytic ring opening of (3) afforded the hydroxy acid (4) which was immediately oxidized to keto acid (5) using chromic acid, cyclodehydration of (5) afforded the 6,8- dimethoxy-3-undecylisocoumarin (6) which on selective demethylation of 8- methoxy group furnished ...
متن کاملSynthesis, nematicidal and antimicrobial properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes.
A new series of bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2-(aryl)-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d][1,3]thiazol-5-yl]phenyl]methanes 6a-r was synthesized by the reaction of arylidine derivative of methylene-bis-thiazolidinones 5a-c with aryl/alkyl hydrazines. Chemical structures of all the new compounds were established by IR, (1)H-NMR, (13)C-NMR, MS and elemental data. The ...
متن کاملSynthesis, characterization and antimicrobial activity of 6-bromo-4-methoxy- 4-(substituted phenyl) iminoflavone
Chalcone and their heterocycalic analogues are known to posses a broad spectram of biological effects. The present study is devoted to the synthesis of 6-bromo-4-methoxy-4-(substituted phenyl) imino flavones. The newly synthesized compounds were screened for their antimicrobial and antifungal activities. 2-hydroxy-5-bromo-4-methoxychalconeimine on refluxing in DMSO for two hrs in presence of ca...
متن کاملSynthesis and Pharmacological Investigation of Novel 2-(3-hydroxy-4-methoxy Phenyl)- 3-substituted-thiazolidin-4-ones as Anticonvulsants
A new series of 2,3-disubstituted thiazolidin-4-ones were obtained by the condensation of appropriate amines with vanillin and mercapto acetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound N-(2-(3hydroxy-4-methoxyphenyl)-4-oxo thiazolidin-3-yl) isonicotinamide (3)...
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ژورنال
عنوان ژورنال: International Letters of Chemistry, Physics and Astronomy
سال: 2015
ISSN: 2299-3843
DOI: 10.18052/www.scipress.com/ilcpa.50.35